Oral Dosage Form New Animal Drugs; Milbemycin Oxime, Lufenuron, and Praziquantel 77 Fed. It is used only in animals, not in humans. Clipboard, Search History, and several other advanced features are temporarily unavailable. Treatment with rifampin can then be restarted one day after completion of praziquantel treatment. The combination milbemycin oxime/lufenuron (trade names Sentinel Flavor Tabs, by Novartis Animal Health, and Program plus) is a parasite control drug in which the active ingredient, milbemycin oxime, eliminates worms, while a second active ingredient, lufenuron, arrests the development of eggs and larvae, preventing them from maturing and continuing the infestation of an animal. Benzoylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs). Ivermectin & Pyrantel ), More about getting RSS News & Updates from DailyMed, Administer the appropriate combination of chewables, 3 MeSH government site. Manufactured by: Bayer HealthCare Pharmaceuticals Inc. Wayne, NJ 07470. The mean number of pups per litter was two animals higher in the lufenuron versus control groups and mean birth weights of pups from treated females in this study was lower than control groups. Eighteen boxes from each of the three kennels were selected for treatment based on faecal egg counts (FECs) at Day -30. Concomitant administration of other drugs that increase the activity of drug metabolizing liver enzymes (P450 inducers), for example, antiepileptic drugs (phenytoin, phenobarbital and carbamazepine), and dexamethasone, may also reduce plasma levels of praziquantel. Description. Last updated on 1969-12-31. Once it is published it will be available on this page in an official form. Abdominal or stomach discomfort with or without nausea, sores, ulcers, or white spots on the lips or in the mouth, swelling of the eyelids, face, lips, hands, or feet, feeling of constant movement of self or surroundings. The milbemycin oxime praziquantel soft chewable tablets of some examples are 1907/2006: Substance name End Use Exposure routes Potential health ef-fects Value Sodium chloride Workers Inhalation Long-term systemic effects The average milk: blood concentration ratio was approximately 60 (i.e. 0061-5357-02. For dogs weighing 5 to 10 kg (11 to 22 pounds), the dosage is tablet of the larger dog size of pill. Milbemycin acts by disrupting nerve transmission within the parasite leading to death of the parasite. Even if your pet appears better, the entire treatment plan should be completed to prevent resurgence. In the dog study, 10 dogs received a single dose of Milpro tablets at a minimum dose of 0.5 mg/kg milbemycin oxime and 5 mg/kg praziquantel 18 days post-infection and 10 dogs received no treatment. Description: SENTINEL SPECTRUM Chews are available in four strengths in color-coded packages for oral administration to dogs and puppies according to their weight. Files, All Mapping Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A4 (C32H45NO7, MW 555.71) and 20% A3 (C31H43NO7, MW 541.68). These actions cause dislodgement of the parasites attachment to the intestinal tract and allows it to be eliminated in the feces (stool). Safety studies in pregnant dogs demonstrated that doses of 0.6X the maximum exposure dose of SENTINEL SPECTRUM Chews, (1.5 mg/kg of milbemycin oxime), administered daily from mating through weaning, resulted in measurable concentrations of milbemycin oxime in milk. For SENTINEL SPECTRUM Chews, the maximum exposure based on product dosing is 2.5 mg/kg for milbemycin oxime, 50.7 mg/kg for lufenuron and 25.1 mg/kg for praziquantel, which is higher than the minimum effective dose used in the safety studies for milbemycin oxime and lufenuron (see below). Animals should be tested for heartworm infection before beginning prevention with Milbemycin/Praziquantel (Milbemax). Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. Epub 2019 Mar 2. (b) Sponsor. Sentinel Spectrum (milbemycin oxime + lufenuron + praziquantel) Heartworm and Flea Prevention Chewables for Dogs is used to prevent heartworm disease and flea populations, and to treat tapeworm, hookworm, roundworm, and whipworm infections in dogs and puppies. Milbemycin oxime is a broad-spectrum antiparasitic active ingredient used in veterinary medicine in dogs and cats against internal parasites (e.g. Out of 56 dogs, 43 were included in the statistical analysis, whereas 13 were excluded because the products under investigation were not administered with food, as required by the label. Vomiting was observed in the 5X treatment group. Information for Owner or Person Treating Animal: Echinococcus multilocularis and Echinococcus granulosus are tapeworms found in wild canids and domestic dogs. Add to Cart. Before Take your doses at least 4 hours apart but not more than 6 hours apart unless directed otherwise by your doctor. -, Otranto D, Dantas-Torres F, Mallia E, Digeronimo PM, Brianti E, Testini G, Traversa D, Lia RP. Now fever, headache and body pains are the indications of paracetamol. Dosage. Tremors were observed twice post-treatment in the 1X treatment group. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Size. Approved for dogs . Copy the URL below and paste it into your RSS Reader application. The dosage for dogs weighing 0.5 kg to 1 kg (1 to 2.2 pounds), is tablet of the small-dog-and-puppy sized pill. Unable to load your collection due to an error, Unable to load your delegates due to an error. Ingredients. The three active ingredients of Sentinel Spectrum are Milbemycin Oxime, Lufenuron and Praziquantel. official website and that any information you provide is encrypted Before For cats weighing 1 to 2 kg (2.2 4.4 pounds), the dose is 1 tablet of the smaller cat-and-kitten size of pill. roundworms ). drug to use by or on the order of a. licensed veterinarian. -, Morgan ER, Cavill L, Curry GE, Wood RM, Mitchell ES. The same shock-like reactions can be observed if Milbemax is administered as a heartworm preventative to a dog or cat with a mature heartworm infestation. Interceptor Plus (milbemycin oxime/praziquantel) is an effective option for protection against heartworm disease, hookworm, roundworm, whipworm, and tapeworm that can be given to puppies as early as 6 weeks of age and weighing at least 2 pounds. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. From January 2009 to July 2011 a placebo controlled and randomized field study was conducted in T. callipaeda endemic areas of Switzerland (CH) and Italy (ITA) involving client-owned animals. Dosage (Posology) and method of administration, Interaction with other medicinal products and other forms of interaction, All rights reserved Pillintrip.com 2018. It belongs to the chemical class of the macrocyclic lactones. Vienaindien , Joekel DE, Schaper R, Deplazes P, arknas M. Parasitol Res. Milbemycin is commonly combined with other drugs to create a variety of prevention medications. Ask your health care provider any questions you may have about how to use praziquantel. Parasit Vectors. For the prevention against heartworm and lungworm. Epub 2020 Jul 6. A study, in which pregnant females were dosed once, at 0.6X maximum exposure dose of SENTINEL SPECTRUM Chews before, on the day of, or shortly after whelping, resulted in no effects on the puppies. Clinda-Guard (Clindamycin) Oral Suspension for Dogs and Cats is a broad-spectrum antibiotic used to treat bacterial infections of the skin, mouth and bones caused by certain types of bacteria in dogs and cats. Anthelmintics are used in the treatment of worm infections. What is milbemycin oxime praziquantel? It should also be noted that Milbemycin Oxime use in dogs can produce skin diseases and conditions and there is no antidote for Milbemycin Oxime poisoning. . Infested animals were orally treated with Milbemax or with placebo tablets on D0 and, if an animal was found still infested with T. callipaeda, also on D7. Concomitant administration of drugs that decrease the activity of drug metabolizing liver enzymes (P 450 inhibitors), for example, cimetidine, ketoconazole, itraconazole, erythromycin may increase plasma levels of praziquantel. and other endoparasite infections in kennel dogs in central Italy. Like ivermectin, milbemycin oxime is a broad-spectrum antiparasitic drug. praziquantel 55268-74-1 TWA 0.5 mg/m3 (OEB 2) Internal Milbemycin Oxime 129496-10-2 TWA 0.1 mg/m3 (OEB2) Internal Derived No Effect Level (DNEL) according to Regulation (EC) No. [Ecology of Thelazia spp. 2000;84:441. 2022 Oct 16;15(1):370. doi: 10.1186/s13071-022-05501-6. Parasitic infections are common in dogs and cats and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, and heartworms). Since parasite destruction within the eye may cause irreversible lesions, ocular cysticercosis must not be treated with this compound. Milbemycin oxime is used as a broad spectrum antiparasitic that is especially effective against worms and mites. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=197a022a-bb94-4058-a4b7-96323e4b311e, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. 0061-5357-01, In well-controlled laboratory studies, neither one dose nor two consecutive doses of SENTINEL SPECTRUM Chews provided 100% effectiveness against induced heartworm infections. Milbehart provides comprehensive coverage against 4 common parasites: HeartwormS 1 mosquito bite is all it takes! Take praziquantel with a full glass of water during meals. 1993. The incidence of nasal discharge, pulmonary congestion, diarrhea/dehydration, and sluggishness was higher in the lufenuron-treated pup group than in the control pup group. This site needs JavaScript to work properly. Conclusions: Dogs randomly allocated to 1 of 3 treatment groups with 14 dogs per group. Milbemycin oxime is classified as a macrocyclic anthelmintic. HHS Vulnerability Disclosure, Help Indications: SENTINEL SPECTRUM Chews are indicated for the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Dipylidium caninum, Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older. CONTRAINDICATIONS Contraindications: There are no known contraindications to the use of SENTINEL SPECTRUM Chews. Bezerra-Santos MA, Mendoza-Roldan JA, Sgroi G, Lia RP, Venegoni G, Solari Basano F, Nele R, Mahabir SP, Borowski S, Geurden T, Otranto D. Parasit Vectors. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins . HHS Vulnerability Disclosure, Help Dosage and Administration: SENTINEL SPECTRUM Chews should be administerd orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, 4.55 mg/lb (10 mg/kg) lufenuron, and 2.28 mg/lb (5 mg/kg) praziquantel. Sentinel Spectrum contains milbemycin oxime, lufenuron, and praziquantel in a palatable formula given once per month. When a single 40 mg/kg dose of praziquantel was administered to these healthy subjects two weeks after discontinuation of rifampin, the mean praziquantel AUC and Cmax were 23% and 35% lower, respectively, than when praziquantel was given alone. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Description. For small cats and kittens weighing 0.5 kg to 1 kg (1 to 2.2 pounds), the dose is tablet of the smaller cat-and-kitten size of pill. At the 5X dose, shallow breathing was noted in two dogs and one dog was unable to stand following two different doses. SENTINEL SPECTRUM Chews may be administered year-round without interruption. 1970;19:476479. Conclusions: Milbemycin/Praziquantel (Milbemax) for small cats and kittens contains 4 mg of milbemycin oxime and 10 mg praziquantel. Data from the phase II and phase III portions of a randomized, double blind, placebo-controlled study supports the use of praziquantel (in combination with albendazole) in the treatment of parenchymal neurocysticercosis. Although these uses are not included in the product labeling, praziquantel is used in certain patients with the following medical conditions: The dosage recommended for the treatment of schistosomiasis is: 20 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. -, Shi YE, Han JJ, Yang WY, Wei DX. Important Information Sentinel Spectrum (milbemycin oxime + lufenuron + praziquantel) Heartworm and Flea Prevention Chewables for Dogs is used to prevent heartworm disease and flea populations, and to treat tapeworm, hookworm, roundworm, and whipworm infections in dogs and puppies. Epub 2018 Mar 25. Would you like email updates of new search results? The aim of the present study was to evaluate the efficacy of helminth control in kennels using different broad-spectrum anthelmintics that are routinely used in canine veterinary practice. Minimum recommended dose rate: 0.5 mg of milbemycin oxime and 5 mg of praziquantel per kg are given once orally. The tablet is coded with BAYER on one side and LG on the reverse side. Prior to receiving the 12.5 mg/kg dose on day 56 of the study, all . Praziquantel is an isoquinolone anthelmintic with the chemical name 2-(Cyclohexylcarbonyl)-1,2,3,6,7,-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one. DailyMed - INTERCEPTOR PLUS- milbemycin oxime and praziquantel tablet, chewable Label: INTERCEPTOR PLUS- milbemycin oxime and praziquantel tablet, chewable NDC Code (s): 58198-5440-1, 58198-5440-2, 58198-5440-3, 58198-5440-4, view more Packager: Elanco US Inc. Category: PRESCRIPTION ANIMAL DRUG LABEL DEA Schedule: None PetPlace may be compensated when you click on or make a purchase using the links in this article. RxNorm, To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. It's a once-monthly, tasty chew, flavored with real chicken that's approved for dogs and puppies 6 weeks or older and 2 pounds or greater. The .gov means its official. Intestinal Nematodes and Cestodes Treatment and Control: Elimination of the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxacara canis, Toxascaris leonina), whipworm (Trichuris vulpis) and tapeworm (Dipylidium caninum, Echinococcus multilocularis, Echinococcus granulosus, Taenia pisiformis) infections in dogs was demonstrated in well-controlled laboratory studies. Praziquantel is used as medication designed to treat parasitic worm infections and is considered by the World Health Organization to be one of the world's most essential medicines in any health system. 2019 Apr;118(4):1321-1324. doi: 10.1007/s00436-019-06275-0. The commercial formulation of milbemycin oxime at the minimal dose of 0.5 mg/kg and 2 mg/k in dogs and cats, respectively, showed a high therapeutic efficacy in curing T. callipaeda infestations. 5.75 mg milbemycin oxime/115 mg lufenuron/57 mg praziquantel 11.5 mg milbemycin oxime/230 mg lufenuron/114 mg praziquantel . Treatment with rifampin can then be restarted one day after completion of praziquantel treatment. No toxicty resulted from these combinations. Results: praziquantel (PRZ) chewables (Milbemax, Novartis; 0.5 mg MO + 5 mg PRZ per kg body weight, according tothemanufacturer'sinstructions;201dogs)andtreatedonce. Flea Prevention and Control: In well-controlled studies, SENTINEL SPECTRUM Chews were effective in preventing flea eggs from hatching, thus providing control of the development of flea populations (Ctenocephalides felis). For small dogs or puppies weighing 1 to 5 kg (2.2 11 pounds), the dose is 1 tablet of the small dog and puppy size. Lufenuron tablets did not cause cholinesterase inhibition nor did they enhance cholinesterase inhibition caused by exposure to organophoshphates. 2005;131:7987. SENTINEL SPECTRUM is available in four strengths, formulated according to the Particular attention was given to the field efficacy and ease-of-use of each product. Lufenuron is a benzoylphenylurea derivative with the following chemical composition: N-[2,5-dichloro-4-(1,1,2,3,3,3,-hexafluoropropoxy)-phenyl-aminocarbonyl]-2,6-difluorobenzamide (C17H8CI2F8N2O3, MW 511.15). For dogs weighing 25 to 50 kg (55 pounds to 110 pounds), the dosage is 2 tablets of the larger dog size of pills. Praziquantel is a veteran isoquinoline anthelmintic introduced in the 1970s (by BAYER). Praziquantel belongs to the family of medicines called anthelmintics. Milbemycin oxime/ praziquantel treatment should be given twice in an interval of 7 days (Motta et al. For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes (see EFFECTIVENESS). Palatability: In a field study of 117 dogs offered SENTINEL SPECTRUM Chews, 113 dogs (96.6%) accepted the product when offered from the hand as if a treat, 2 dogs (1.7%) accepted it from the bowl with food, 1 dog (0.9%) accepted it when it was placed in the dog's mouth, and 1 dog (0.9%) refused it. Plasma praziquantel concentrations were undetectable in 7 out of 10 subjects. Longitudinal study for anthelmintic efficacy against intestinal helminths in naturally exposed Lithuanian village dogs: critical analysis of feasibility and limitations. Milbemycin-based Heartworm medications are also given orally once per month. Traversa D. Pet roundworms and hookworms: a continuing need for global worming. The https:// ensures that you are connecting to the Praziquantel may also be used for other worm infections as determined by your doctor. The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/ lethargy, ataxia, anorexia, convulsions, weakness, and salivation. Their development and transmission. Milbemycin Oxime/Praziquantel uses consists of Milbemycin Oxime, Praziquantel. Attention! If it less than 4 hours until your next dose, contact your doctor to see if you need to establish a new dosing schedule. T. Bihr, G. Conboy Biology, Medicine A rising-dose safety study conducted in rough-coated Collies resulted in ataxia, pyrexia, and periodic recumbency in one of fourteen dogs administered milbemycin oxime at 12.5 mg/kg (5X the maximum exposure dose of SENTINEL SPECTRUM Chews). 2014;7(1):67. doi: 10.1186/1756-3305-7-67. Vomiting was seen in all treatment groups but at a higher incidence in the 3X and 5X groups. 0061-5354-02, The study was conducted in 3 public kennels in the Campania region (southern Italy). How Supplied: SENTINEL SPECTRUM Chews are available in four strengths, formulated according to the weight of the dog. Thelazia callipaeda(Spirurida, Thelaziidae) in wild animals: Report of new host species and ecological implications. These infections are also known as snail fever, schistosomiasis, or bilharziasis. Accessibility The product should be administered with or after some food. This item: Milpro 12.5 mg / 125 mg (milbemycin oxime, praziquantel) Worming for dogs 5-25 kg, 4 tablets 62.40 47.20 1 Envayr (febantel, pyrantel, praziquantel) Wormer for Dogs 20 tablets Milbemycin oxime disrupts the nerve transmission in many species of invertebrates and this helps to protect our pets against roundworm, heartworm and hookworm. [PubChem]. The tablets should be washed down unchewed with water during meals. If of a tablet is required, this is best achieved by breaking the segment from the outer end. An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. Effects of aggregation and sample size on composite faecal egg counts in sheep. Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. Approved for dogs . Vet Parasitol. Milbemycin oxime, praziquantel: Oral: A rising-dose safety study conducted in rough-coated Collies resulted in ataxia, pyrexia, and periodic recumbency in one of fourteen dogs administered milbemycin oxime at 12.5 mg/kg (5 times the maximum exposure dose of Interceptor Plus). All three drugs were 100% effective against D.caninum. Storage Information: Store in a dry place at controlled room temperature, between 59 and 77F (15-25C). lightheadedness, dizziness, or fainting. In patients receiving rifampin, for example, as part of a combination regimen for the treatment of tuberculosis, alternative agents for schistosomiasis should be considered. Each tablet is formulated to provide a minimum of 0.23 mg/lb (0.5 mg/kg) body weight of milbemycin oxime. It is scheduled to be published on 01/27/2012. and 228 mg. praziquantel. The invention discloses veterinary milbemycin oxime praziquantel soft chewable tablets with good palatability and a preparation method of the veterinary milbemycin oxime praziquantel soft chewable tablets. Vet Parasitol. Grapefruit juice was reported to produce a 1.6-fold increase in the Cmax and a 1.9-fold increase in the AUC of praziquantel. Helminths: Treatment of infections in patients 1 year caused by the following: All species of Schistosoma (eg, Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium) and the liver flukes Clonorchis sinensis/Opisthorchis viverrini. If you miss a dose of praziquantel, take it as soon as possible. Dosage and Administration: SENTINEL SPECTRUM Chews should be administerd orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, 4.55 mg/lb (10 mg/kg . -, Grandemange E, Claerebout E, Genchi C, Franc M. Field evaluation of the efficacy and the safety of a combination of oxantel/pyrantel/praziquantel in the treatment of naturally acquired gastrointestinal nematode and/or cestode infestations in dogs in Europe. Intestinal Nematode and Cestode Treatment and Control: Information for Owner or Person Treating Animal: milbemycin oxime, lufenuron, praziquantel. FDA Safety Recalls (Animal Drug), Clinical Trials, It impairs the function of the parasites sucker and stimulates movement of the worm. Milbemax is safe in collie breeds and collie mixed breeds. Methods: From January 2009 to July 2011 a placebo controlled and randomized field study was conducted in T. callipaeda endemic areas of Switzerland (CH) and Italy (ITA) involving client-owned animals. and transmitted securely. All dogs were treated on Day 0 and sampled on Days 0, 7, 14 and 21 for copromicroscopic analyses. AmJTrop Med Hyg. The milbemycin oxime praziquantel soft chewable tablet comprises the following components in parts by weight: 0.1-1 part of milbemycin oxime . Each strength is available in color-coded packages of six chewable tablets each. The .gov means its official. Citations, PRINCIPAL DISPLAY PANEL - 6 Chewable Blister Pack Carton - 5354-02, PRINCIPAL DISPLAY PANEL - 6 Chewable Blister Pack Carton - 5355-02, PRINCIPAL DISPLAY PANEL - 6 Chewable Blister Pack Carton - 5356-02, PRINCIPAL DISPLAY PANEL - 6 Chewable Blister Pack Carton - 5357-02, (What Manufactured for: Intervet Inc (d/b/a Merck Animal Health)2 Giralda FarmsMadison, NJ 07940Approved by FDA under NADA # 141-333. Leishmania infantum, Dirofilaria spp. View NDC Code(s)NEW! Milbemax tablets for cats (2-8kg): 16mg milbemycin oxime (dose range 2-4mg/kg) 40mg praziquantel (dose range 5-10mg/kg) Can be given to cats over 2kg and 6 weeks of age. Key Features: Prevents heartworm disease It is not used against agricultural and household pests. 0-2 parts of a coloring agent, a proper amount of an antioxidant and a proper amount of water, wherein the hardness of the milbemycin oxime praziquantel soft chewable tablet is 3.0-6.0 kg. Chewable Tablet, lufenuron 230 MG / milbemycin oxime 11.5 MG / praziquantel 114 MG Chewable Tablet [Sentinel Spectrum], milbemycin oxime 2.3 MG / lufenuron 46 MG / praziquantel 22.8 MG Chewable Tablet, lufenuron 46 MG / milbemycin oxime 2.3 MG / praziquantel 22.8 MG Chewable Tablet, sentinel spectrum 2.3 MG / 46 MG / 22.8 MG for dogs 2-8 lbs. Each tablet contains: (1) 2.3 milligrams (mg) milbemycin oxime, 46 mg lufenuron, and 22.8 mg praziquantel ; (2) 5.75 mg milbemycin oxime, 115 mg lufenuron, and 57 mg praziquantel ; (3) 11.5 mg milbemycin oxime, 230 mg lufenuron, and 114 mg praziquantel; or H. How Supplied . On D14 nematodes were flushed from the conjunctiva, identified and counted. spectrum chews(milbemycin oxime lufenuron praziquantel), 2.3 mg milbemycin oxime 46 mg lufenuron 22.8 mg praziquantelCAUTION: Federal (USA) law resricts this drug to use by or on the order of a licensed veterinarian, 8.1-25lbsFOR DOGS AND PUPPIESSIX WEEKS OF AGE AND OLDER, 5.75 mg milbemycin oxime 115 mg lufenuron 57 mg praziquantelCAUTION: Federal (USA) law resricts this drug to use by or on the order of a licensed veterinarian, 25.1-50lbsFOR DOGS AND PUPPIESSIX WEEKS OF AGE AND OLDER, 11.5 mg milbemycin oxime 230 mg lufenuron 114 mg praziquantelCAUTION: Federal (USA) law resricts this drug to use by or on the order of a licensed veterinarian, 50.1-100lbsFOR DOGS AND PUPPIESSIX WEEKS OF AGE AND OLDER, 23 mg milbemycin oxime 460 mg lufenuron 228 mg praziquantelCAUTION: Federal (USA) law resricts this drug to use by or on the order of a licensed veterinarian, Report Adverse Events (Animal Drug), Milbemycin Oxime, also known as Interceptor, is used to control hookworm, roundworm, and certain whipworm infections in dogs and cats. 23.0 mg milbemycin oxime/460 mg lufenuron/228 mg praziquantel . Files, Presentations Disclaimer, National Library of Medicine Adverse Reactions: The following adverse reactions have been reported in dogs after administration of milbemycin oxime, lufenuron, or praziquantel: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, salivation, and weakness. milbemycin oxime 23 MG / lufenuron 460 MG / praziquantel 228 MG Chewable Tablet is classified as a macrocyclic anthelmintic. Vet Clin North Am Small Anim Pract. & Articles, All Independence America Holdings Corp. 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